Novel Role for PD-1:PD-L1 as Mediator of Pulmonary Vascular Endothelial Cell Functions in Pathogenesis of Indirect ARDS in Mice

Novel Role for PD-1:PD-L1 as Mediator of Pulmonary Vascular Endothelial Cell Functions in Pathogenesis of Indirect ARDS in Mice

Deficiency of the co-inhibitory receptor, Programmed cell death receptor (PD)-1, provides a survival benefit in our murine shock/sepsis model for the development of indirect acute respiratory distress syndrome (iARDS). Further, of clinical significance, patients that develop ARDS express increased P...

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Bibliographic Details
Main Authors: Joanne Lomas-Neira, Sean F. Monaghan, Xin Huang, Eleanor A. Fallon, Chun-Shiang Chung, Alfred Ayala
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
Angiopoietin-1 and-2
Tie2
lung permeability
innate immunity
lung injury
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03030/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03030/full

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