The role of substantia nigra pars reticulata in modulating clonic seizures is determined by testosterone levels during the immediate postnatal period

The role of substantia nigra pars reticulata in modulating clonic seizures is determined by testosterone levels during the immediate postnatal period

GABAergic activation of substantia nigra pars reticulata (SNR) at postnatal day (PN) 15 has sex-specific features on seizure control in vivo and electrophysiological responses in vitro. In males, the GABAA-receptor agonist muscimol has proconvulsant effects and induces depolarizing responses. In fem...

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Bibliographic Details
Main Authors: Filippo S. Giorgi, Jana Velíšková, Ondřej Chudomel, Andreas Kyrozis, Solomon L. Moshé
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Neurobiology of Disease
Subjects:
Substantia nigra
Sex hormones
Muscimol infusions
Seizure
GABA
Patch clamp
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002129

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http://www.sciencedirect.com/science/article/pii/S0969996106002129

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