3,3’-Diindolylmethane Enhances Paclitaxel Sensitivity by Suppressing DNMT1-Mediated KLF4 Methylation in Breast Cancer

3,3’-Diindolylmethane Enhances Paclitaxel Sensitivity by Suppressing DNMT1-Mediated KLF4 Methylation in Breast Cancer

Paclitaxel (PTX) is a first-line chemotherapeutic drug for the treatment of breast cancer, but drug resistance seriously limits its clinical use. The aim of the present work was to explore the effect of 3,3’-diindolylmethane (DIM) on PTX sensitivity and its possible mechanism in breast cancer. The e...

Full description

Bibliographic Details
Main Authors: Fenfen Xiang, Zhaowei Zhu, Mengzhe Zhang, Jie Wang, Zixi Chen, Xiaoxiao Li, Tao Zhang, Qing Gu, Rong Wu, Xiangdong Kang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
breast cancer
paclitaxel
sensitivity
KLF4
DNMT1
DIM
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.627856/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.627856/full

Similar Items