Hoxa9 transduction induces hematopoietic stem and progenitor cell activity through direct down-regulation of geminin protein.

Hoxa9 transduction induces hematopoietic stem and progenitor cell activity through direct down-regulation of geminin protein.

Hoxb4, a 3'-located Hox gene, enhances hematopoietic stem cell (HSC) activity, while a subset of 5'-located Hox genes is involved in hematopoiesis and leukemogenesis, and some of them are common translocation partners for Nucleoporin 98 (Nup98) in patients with leukemia. Although these Hox...

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Bibliographic Details
Main Authors: Yoshinori Ohno, Shin'ichiro Yasunaga, Salima Janmohamed, Motoaki Ohtsubo, Keita Saeki, Toshiaki Kurogi, Keichiro Mihara, Norman N Iscove, Yoshihiro Takihara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3543444?pdf=render

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http://europepmc.org/articles/PMC3543444?pdf=render

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