SPAR – a randomised, placebo-controlled phase II trial of simvastatin in addition to standard chemotherapy and radiation in preoperative treatment for rectal cancer: an AGITG clinical trial

SPAR – a randomised, placebo-controlled phase II trial of simvastatin in addition to standard chemotherapy and radiation in preoperative treatment for rectal cancer: an AGITG clinical trial

Abstract Background Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and reduced acute and late toxicities of pelvic radiation. Major tumour regre...

Full description

Bibliographic Details
Main Authors: Michael B. Jameson, Kirsten Gormly, David Espinoza, Wendy Hague, Gholamreza Asghari, Grahame Mark Jeffery, Timothy Jay Price, Christos Stelios Karapetis, Michael Arendse, James Armstrong, John Childs, Frank A. Frizelle, Sam Ngan, Andrew Stevenson, Martinus Oostendorp, Stephen P. Ackland
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Cancer
Subjects:
Rectal cancer
Chemoradiation
Statins
HMG-coA reductase inhibitor
Tumour regression grading
Online Access:https://doi.org/10.1186/s12885-019-6405-7

Internet

https://doi.org/10.1186/s12885-019-6405-7

Similar Items