Is alpha-synuclein loss-of-function a contributor to parkinsonian pathology? Evidence from non-human primates

Is alpha-synuclein loss-of-function a contributor to parkinsonian pathology? Evidence from non-human primates

Accumulation of alpha-synuclein (α-syn) in Lewy bodies and neurites of midbrain dopamine neurons is diagnostic for Parkinson’s disease (PD), leading to the proposal that PD is a toxic gain-of-function synucleinopathy. Here we discuss the alternative viewpoint that α-syn displacement from synapses b...

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Bibliographic Details
Main Authors: Timothy J Collier, D Eugene Redmond, Kathy eSteece-Collier, Jack W Lipton, Fredric P Manfredsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Neuroscience
Subjects:
Dopamine
Parkinson Disease
Substantia Nigra
non-human primates
alpha-synuclien
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00012/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00012/full

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