Comparison of the Expression Changes after Botulinum Toxin Type A and Minocycline Administration in Lipopolysaccharide-Stimulated Rat Microglial and Astroglial Cultures

Comparison of the Expression Changes after Botulinum Toxin Type A and Minocycline Administration in Lipopolysaccharide-Stimulated Rat Microglial and Astroglial Cultures

Botulinum neurotoxin type A (BoNT/A) and minocycline are potent drugs used in clinical therapies. The primary molecular mechanism of BoNT/A is the cleavage of SNARE proteins, which prevents cells from releasing neurotransmitters from vesicles, while the effects of minocycline are related to the inhi...

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Bibliographic Details
Main Authors: Joanna Mika, Anna Piotrowska, Katarzyna Popiolek-Barczyk, Flaminia Pavone
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
BoNT/A
inflammation
inflammatory factors
intracellular pathways
TLR2
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00141/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00141/full

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