Comparative Label-Free Mass Spectrometric Analysis of Mildly versus Severely Affected mdx Mouse Skeletal Muscles Identifies Annexin, Lamin, and Vimentin as Universal Dystrophic Markers

Comparative Label-Free Mass Spectrometric Analysis of Mildly versus Severely Affected mdx Mouse Skeletal Muscles Identifies Annexin, Lamin, and Vimentin as Universal Dystrophic Markers

The primary deficiency in the membrane cytoskeletal protein dystrophin results in complex changes in dystrophic muscles. In order to compare the degree of secondary alterations in differently affected subtypes of skeletal muscles, we have conducted a global analysis of proteome-wide changes in vario...

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Bibliographic Details
Main Authors: Ashling Holland, Michael Henry, Paula Meleady, Claudia K. Winkler, Mirjam Krautwald, Heinrich Brinkmeier, Kay Ohlendieck
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Molecules
Subjects:
diaphragm
dystrophin
dystrophinopathy
Duchenne muscular dystrophy
extensor digitorum longus
flexor digitorum brevis
interosseus
muscle pathology
soleus
skeletal muscle proteome
Online Access:http://www.mdpi.com/1420-3049/20/6/11317

Internet

http://www.mdpi.com/1420-3049/20/6/11317

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