Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library

Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library

The application of a cell-based growth inhibition on a library of skeletally different glycomimetics allowed for the selection of a hexahydro-2H-furo[3,2-b][1,4]oxazine compound as candidate inhibitors of MDA-MB-231 cell growth. Subsequent synthesis of analogue compounds and preliminary biological s...

Full description

Bibliographic Details
Main Authors:	Elena Lenci, Riccardo Innocenti, Alessio Biagioni, Gloria Menchi, Francesca Bianchini, Andrea Trabocchi
Format:	Article
Language:	English
Published:	MDPI AG 2016-10-01
Series:	Molecules
Subjects:	heterocycles sugars chemical diversity cancer
Online Access:	http://www.mdpi.com/1420-3049/21/10/1405

Similar Items

Diversity-Oriented Synthesis and Chemoinformatic Analysis of the Molecular Diversity of sp3-Rich Morpholine Peptidomimetics
by: Elena Lenci, et al.
Published: (2018-10-01)

Combination of multicomponent KA2 and Pauson–Khand reactions: short synthesis of spirocyclic pyrrolocyclopentenones
by: Riccardo Innocenti, et al.
Published: (2020-02-01)

Potential Effects of Chrysin on MDA-MB-231 Cells
by: Maimunah Ahmad, et al.
Published: (2010-03-01)

Shock wave impact on the viability of MDA-MB-231 cells.
by: Yingqian Liao, et al.
Published: (2020-01-01)

Citral induced apoptosis in MDA-MB-231 spheroid cells
by: Siyamak Ebrahimi Nigjeh, et al.
Published: (2018-02-01)

Identification of cellular targets for inhibiting MDA-MB-231 migration and invasion
by: Ming-Xian Yang, et al.
Published: (2019)

Berberine Inhibits MDA-MB-231 Cells by Attenuating Their Inflammatory Responses
by: Lina Zhao, et al.
Published: (2020-01-01)

Proteomics Profiling of KAIMRC1 in Comparison to MDA-MB231 and MCF-7
by: Bandar Alghanem, et al.
Published: (2020-06-01)

Effects of osteopontin inhibition on radiosensitivityof MDA-MB-231 breast cancer cells
by: Hahnel Antje, et al.
Published: (2010-09-01)

Different Mechanisms of Berberine-induced Anti-proliferation Effects in Triple Negative Breast Cancer MDA-MB-231 and MDA-MB-468 Cell Lines
by: Yi-Hsiu Tsai, et al.
Published: (2017)

Amikacin Suppresses Human Breast Cancer Cell MDA-MB-231 Migration and Invasion
by: Yun-Hsin Wang, et al.
Published: (2020-11-01)

Mannoside-Modified Branched Gold Nanoparticles for Photothermal Therapy to MDA-MB-231 Cells
by: Han-Chen Lin, et al.
Published: (2020-04-01)

Polyphenols sensitization potentiates susceptibility of MCF-7 and MDA MB-231 cells to Centchroman.
by: Neetu Singh, et al.
Published: (2012-01-01)

Arctigenin Enhances the Cytotoxic Effect of Doxorubicin in MDA-MB-231 Breast Cancer Cells
by: Kyu-Shik Lee, et al.
Published: (2020-04-01)

Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells.
by: Beatrice Bachmeier, et al.
Published: (2011-01-01)

Characterization of Triple-Negative Breast Cancer MDA-MB-231 Cell Spheroid Model
by: Huang Z, et al.
Published: (2020-06-01)

Allyl Isothiocyanate Exhibits No Anticancer Activity in MDA-MB-231 Breast Cancer Cells
by: Md. Abu Sayeed, et al.
Published: (2018-01-01)

Phenotypic Switch Induced by Simulated Microgravity on MDA-MB-231 Breast Cancer Cells
by: Maria Grazia Masiello, et al.
Published: (2014-01-01)

Optimized Method for Untargeted Metabolomics Analysis of MDA-MB-231 Breast Cancer Cells
by: Amanda L. Peterson, et al.
Published: (2016-09-01)

The effect of laser irradiation on the viability of human breast cancer cell, MDA-MB-231
by: Badruzzaman, A., et al.
Published: (2016)

Experimental anti-metastic potential and mechanism of wedelolactone and demethylwedelolactone in MDA-MB-231 cells
by: Shien-Kai, et al.
Published: (2010)

Protoapigenone induces apoptosis in the human breast cancer cell line MDA-MB-231
by: Ching-Yi Tsai, et al.
Published: (2006)

Pristimerin induces apoptosis in the human breast cancer cell line MDA-MB-231
by: Mei-Ling Chan, et al.
Published: (2004)

Withanolides induce apoptosis in the human breast cancer cell line MDA-MB-231
by: Yung-Hsien Chen, et al.
Published: (2007)

Investigate the role of GCIP in malignant human breast cancer cell MDA-MB-231
by: Chia-Hua Cheng, et al.
Published: (2006)

The chemosensitizer ferulic acid enhances epirubicin-induced apoptosis in MDA-MB-231 cells
by: Wei-Jia Cheng, et al.
Published: (2020-10-01)

Antibacterial Synthetic Peptides Derived from Bovine Lactoferricin Exhibit Cytotoxic Effect against MDA-MB-468 and MDA-MB-231 Breast Cancer Cell Lines
by: Yerly Vargas Casanova, et al.
Published: (2017-09-01)

Expression and function of voltage gated proton channels (Hv1) in MDA-MB-231 cells.
by: Dan J Bare, et al.
Published: (2020-01-01)

Growth Inhibition of MDA-MB-231 Cell Line by Peptides Designed based on uPA
by: Parastoo Tarighi, et al.
Published: (2015-10-01)

cmvIL-10 stimulates the invasive potential of MDA-MB-231 breast cancer cells.
by: Cendy A Valle Oseguera, et al.
Published: (2014-01-01)

Effect of non-thermal atmospheric pressure plasma on MDA-MB-231 breast cancer cells
by: Ramin Mehrabifard, et al.
Published: (2017-09-01)

Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival.
by: Duane D Hall, et al.
Published: (2014-01-01)

Cytotoxic effect of ICD-85 (venom-derived peptides) on MDA-MB-231 cell line
by: A Zare Mirakabadi, et al.
Published: (2008-01-01)

Cytotoxicity of Biologically Synthesized Silver Nanoparticles in MDA-MB-231 Human Breast Cancer Cells
by: Sangiliyandi Gurunathan, et al.
Published: (2013-01-01)

Inhibition of IGF signalling pathway in MDA-MB-231 triple negative breast cancer cells
by: Chandran S, et al.
Published: (2012-07-01)

The Effect of Histone Hyperacetylation on Viability of Basal-Like Breast Cancer Cells MDA-MB-231
by: Aliasghar Rahimian, et al.
Published: (2017-06-01)

TFDP3 regulates the apoptosis and autophagy in breast cancer cell line MDA-MB-231.
by: Ling-Yu Ding, et al.
Published: (2018-01-01)

Goniothalamin Induces Necroptosis and Anoikis in Human Invasive Breast Cancer MDA-MB-231 Cells
by: Patompong Khaw-on, et al.
Published: (2019-08-01)

Anti-metastatic mechanism of ovatodiolide and cardiotoxin III in MDA-MB-231 breast cancer cells
by: Pei-Chien Tsai, et al.
Published: (2012)

Induction of Autophagy in MDA-MB-231 Breast Cancer Cells by Ethanol Extract of Momordica charantia
by: Chun-hao Tsai, et al.
Published: (2012)