Lupus Autoimmunity and Metabolic Parameters Are Exacerbated Upon High Fat Diet-Induced Obesity Due to TLR7 Signaling

Lupus Autoimmunity and Metabolic Parameters Are Exacerbated Upon High Fat Diet-Induced Obesity Due to TLR7 Signaling

Systemic lupus erythematosus (SLE) patients have increased prevalence of metabolic syndrome but the underlying mechanisms are unknown. Toll-like receptor 7 (TLR7) that detects single stranded-RNA plays a key role in antimicrobial host defense and also contributes to the initiation and progression of...

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Bibliographic Details
Main Authors: Noël Hanna Kazazian, Yawen Wang, Annie Roussel-Queval, Laetitia Marcadet, Lionel Chasson, Caroline Laprie, Benoit Desnues, Jonathan Charaix, Magali Irla, Lena Alexopoulou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus (SLE)
toll-like receptor 7 (TLR7)
metabolic syndrome
obesity
animal model
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02015/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02015/full

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