Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species

Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species

Here, we examine the mechanism by which plasmacytoid dendritic cells (pDCs) and type I interferons promote humoral autoimmunity. In an amyloid-induced experimental autoimmune model, neutrophil depletion enhanced anti-nuclear antibody development, which correlated with heightened IFN-γ production by...

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Bibliographic Details
Main Authors: Xinfang Huang, Jingjing Li, Stephanie Dorta-Estremera, Jeremy Di Domizio, Scott M. Anthony, Stephanie S. Watowich, Daniel Popkin, Zheng Liu, Philip Brohawn, Yihong Yao, Kimberly S. Schluns, Lewis L. Lanier, Wei Cao
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715007615

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http://www.sciencedirect.com/science/article/pii/S2211124715007615

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