Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: Beneficial effect of pentoxifylline

Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: Beneficial effect of pentoxifylline

Cell-attached patch-clamp recordings on native striated myofibers from adult dystrophic mdx mice revealed a higher occurrence and open probability compared to non-dystrophic wild-type myofibers of a 30 pS voltage-insensitive Ca2+-permeable channel, inhibited by Gd3+, streptomycin and ruthenium red....

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Bibliographic Details
Main Authors: Jean-François Rolland, Annamaria De Luca, Rosa Burdi, Francesca Andreetta, Paolo Confalonieri, Diana Conte Camerino
Format: Article
Language:English
Published: Elsevier 2006-12-01
Series:Neurobiology of Disease
Subjects:
In vivo exercise
Muscular dystrophy
mdx mouse
Patch-clamp recordings
Voltage-insensitive cation channels
IGF-1 and cAMP modulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001987

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http://www.sciencedirect.com/science/article/pii/S0969996106001987

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