Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity

Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity

Cisplatin and other platinum(II) analogs are widely used in clinical practice as anti-cancer drugs for a wide range of tumors. The primary mechanism by which they exert their action is through the formation of adducts with genomic DNA. However, multiple cellular targets by platinum(II) complexes hav...

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Bibliographic Details
Main Authors: Nuno Martinho, Tânia C. B. Santos, Helena F. Florindo, Liana C. Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Physiology
Subjects:
cisplatin mechanism of action
chemotherapeutic
membrane biophysical properties
membrane fluidity
membrane interactions
membrane permeability
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01898/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.01898/full

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