Hydrogen Sulfide Mediates Tumor Cell Resistance to Thioredoxin Inhibitor

Hydrogen Sulfide Mediates Tumor Cell Resistance to Thioredoxin Inhibitor

Thioredoxin (Trx) is a pro-oncogenic molecule that underlies tumor initiation, progression and chemo-resistance. PX-12, a Trx inhibitor, has been used to treat certain tumors. Currently, factors predicting tumor sensitivity to PX-12 are unclear. Given that hydrogen sulfide (H2S), a gaseous bio-media...

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Bibliographic Details
Main Authors: Zhimin Mao, Xiawen Yang, Sayumi Mizutani, Yanru Huang, Zhen Zhang, Hideyuki Shinmori, Kun Gao, Jian Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
PX-12
H2S
sulfhydration
chemotherapy
drug resistance
Trx
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00252/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00252/full

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