Expression, purification and biological effect of a novel single chain Fv antibody and protamine fusion protein for the targeted delivery of siRNAs to FGFR3 positive cancer cells

Expression, purification and biological effect of a novel single chain Fv antibody and protamine fusion protein for the targeted delivery of siRNAs to FGFR3 positive cancer cells

Background: Gain-of-function of fibroblast growth factor receptor 3 (FGFR3) is involved in the pathogenesis of many tumors. More and more studies have focused on the potential usage of therapeutic single-chain Fv (ScFv) antibodies against FGFR3. RNA interference (RNAi) has been considered as a promi...

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Bibliographic Details
Main Authors: Chongsen Zang, Zixuan Liu, Kunmeng Yang, Rui Li, Xinxin Wang, Jizhou Zhang, Yechen Xiao
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Electronic Journal of Biotechnology
Subjects:
Bacterial culture
Bladder cancer
Carrier
Escherichia coli
Fusion protein
Inclusion body
Internalization
Pathogenesis
Receptor
Single-chain Fv antibody
Therapeutic
Online Access:http://www.sciencedirect.com/science/article/pii/S0717345817300313

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http://www.sciencedirect.com/science/article/pii/S0717345817300313

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