Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Seeded with hTGF-β1-Releasing PLGA Microcarrier

Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Seeded with hTGF-β1-Releasing PLGA Microcarrier

Tissue engineering strategies can be relevant for cartilage repair and regeneration. A collagen matrix was functionalized with the addition of poly-lactic-co-glycolic acid microcarriers (PLGA-MCs) carrying a human Transforming Growth Factor β1 (hTFG-β1) payload, to provide a 3D biomimetic environmen...

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Bibliographic Details
Main Authors: Erwin Pavel Lamparelli, Joseph Lovecchio, Maria Camilla Ciardulli, Valentina Giudice, Tina P. Dale, Carmine Selleri, Nicholas Forsyth, Emanuele Giordano, Nicola Maffulli, Giovanna Della Porta
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceutics
Subjects:
human bone marrow mesenchymal stem cells
hTGF-β1 controlled delivery
PLGA microcarriers
3D collagen scaffold
chondrogenic commitment
perfusion bioreactor system
Online Access:https://www.mdpi.com/1999-4923/13/3/399

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https://www.mdpi.com/1999-4923/13/3/399

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