Insights into the Influence of Specific Splicing Events on the Structural Organization of LRRK2

Insights into the Influence of Specific Splicing Events on the Structural Organization of LRRK2

Leucine-rich repeat kinase 2 (LRRK2) is a large protein of unclear function. Rare mutations in the LRRK2 gene cause familial Parkinson’s disease (PD) and inflammatory bowel disease. Genome-wide association studies (GWAS) have revealed significant association of the abovementioned diseases...

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Bibliographic Details
Main Authors: Dimitrios Vlachakis, Nikolaos E. Labrou, Costas Iliopoulos, John Hardy, Patrick A. Lewis, Hardy Rideout, Daniah Trabzuni
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
LRRK2 mRNA expression
Human brain substantia nigra
Parkinson’s disease (PD)
ROC/COR domain splicing events
WD40 domain in protein structure
Online Access:http://www.mdpi.com/1422-0067/19/9/2784

Internet

http://www.mdpi.com/1422-0067/19/9/2784

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