AVANÇOS QUÍMICOS NO PLANEJAMENTO E DESENVOLVIMENTO DE DERIVADOS DO PARACETAMOL

AVANÇOS QUÍMICOS NO PLANEJAMENTO E DESENVOLVIMENTO DE DERIVADOS DO PARACETAMOL

Acetaminophen or paracetamol is a widely used analgesic and antipyretic drug and appears to be safe if used at normal therapeutic doses, but in large doses produce liver and / or kidney damage in humans and experimental animals. Prostaglandin endoperoxide synthase (PGES) and cytochrome P-450 are the...

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Bibliographic Details
Main Authors: Rosivaldo S. Borges, Ana Carolina S. P. S. Jesus, Laice F. Cardoso, Clícia L. Neri, Roberto B. Morais, Valéria A. Barros, Albérico B. F. da Silva
Format: Article
Language:English
Published: Sociedade Brasileira de Química
Series:Química Nova
Subjects:
paracetamol
acetaminophen
derivatives
toxicity
design
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422018001001167&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422018001001167&lng=en&tlng=en

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