circAFF1 Aggravates Vascular Endothelial Cell Dysfunction Mediated by miR-516b/SAV1/YAP1 Axis

circAFF1 Aggravates Vascular Endothelial Cell Dysfunction Mediated by miR-516b/SAV1/YAP1 Axis

Pathological vascular endothelial damage caused by hypoxia is the basis of many vascular-related diseases. However, the role of circular RNA in hypoxic vascular injury is still poorly understood. Here, we found that hypoxia induced AFF1 circular RNA (circAFF1) can activate the SAV1/YAP1 and lead to...

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Bibliographic Details
Main Authors: Hong-guang Wang, Hua Yan, Chen Wang, Mi-mi Li, Xin-ze Lv, Hai-dong Wu, Zhan-hai Fang, Dong-li Mo, Zhi-yuan Zhang, Bin Liang, Ke-guan Lai, Jing-yu Bao, Xue-jia Yang, Hong-juan Zhao, Shuang Chen, Yi-mu Fan, Xiao-guang Tong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Physiology
Subjects:
vascular endothelial cell
subarachnoid hemorrhage
hypoxic
circAFF1
YAP1
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00899/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00899/full

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