CTCF modulates allele-specific sub-TAD organization and imprinted gene activity at the mouse Dlk1-Dio3 and Igf2-H19 domains

CTCF modulates allele-specific sub-TAD organization and imprinted gene activity at the mouse Dlk1-Dio3 and Igf2-H19 domains

Abstract Background Genomic imprinting is essential for mammalian development and provides a unique paradigm to explore intra-cellular differences in chromatin configuration. So far, the detailed allele-specific chromatin organization of imprinted gene domains has mostly been lacking. Here, we explo...

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Bibliographic Details
Main Authors: David Llères, Benoît Moindrot, Rakesh Pathak, Vincent Piras, Mélody Matelot, Benoît Pignard, Alice Marchand, Mallory Poncelet, Aurélien Perrin, Virgile Tellier, Robert Feil, Daan Noordermeer
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Genome Biology
Subjects:
Genomic imprinting
3D genome organization
Dlk1
Meg3
Igf2
CTCF
Online Access:https://doi.org/10.1186/s13059-019-1896-8

Internet

https://doi.org/10.1186/s13059-019-1896-8

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