Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice.

Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice.

<h4>Background</h4>A major group of murine inhibitory receptors on Natural Killer (NK) cells belong to the Ly49 receptor family and recognize MHC class I molecules. Infected or transformed target cells frequently downmodulate MHC class I molecules and can thus avoid CD8(+) T cell attack,...

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Main Authors: Petter Brodin, Tadepally Lakshmikanth, Ramit Mehr, Maria H Johansson, Adil Doganay Duru, Adnane Achour, Mali Salmon-Divon, Klas Kärre, Petter Höglund, Sofia Johansson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20957233/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20957233/pdf/?tool=EBI

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