Central Administration of 5Z-7-Oxozeaenol Protects Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Microglia Activation

Central Administration of 5Z-7-Oxozeaenol Protects Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Microglia Activation

Transforming growth factor β-activated kinase 1 (TAK1), a vital upstream integrator of multiple pro-inflammatory signaling pathways, mediates the production of pro-inflammatory cytokines, chemokines, and adhesion molecules. Investigations targeting TAK1 provide new therapeutic options for chronic in...

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Bibliographic Details
Main Authors: Lingli Lu, Xiuping Zhang, Huichun Tong, Wenlong Zhang, Pingyi Xu, Shaogang Qu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
5Z-7-oxozeaenol
transforming growth factor β-activated kinase 1
experimental autoimmune encephalomyelitis
microglia
NF-κB
mitogen-activated protein kinase
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00789/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00789/full

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