Spectrum of TP53 Mutations in BRCA1/2 Associated High-Grade Serous Ovarian Cancer

Spectrum of TP53 Mutations in BRCA1/2 Associated High-Grade Serous Ovarian Cancer

Objective: Mutations in TP53 lead to loss of function (LOF) or gain of function (GOF) of the corresponding protein p53 and produce a different effect on the tumor. Our goal was to determine the spectrum of somatic TP53 variants in BRCA1/2 associated high-grade serous ovarian cancer (HGSOC).Methods:...

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Bibliographic Details
Main Authors: Ulyana A. Boyarskikh, L. F. Gulyaeva, A. M. Avdalyan, A. A. Kechin, E. A. Khrapov, D. G. Lazareva, N. E. Kushlinskii, A. Melkonyan, A. Arakelyan, Maxim Leonidovich Filipenko
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
TP53 somatic mutations
p53 expression
gain of function
loss of function
BRCA1/2 carriers
ovarian cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01103/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01103/full

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