Wnt5a Promotes Cortical Neuron Survival by Inhibiting Cell-Cycle Activation

Wnt5a Promotes Cortical Neuron Survival by Inhibiting Cell-Cycle Activation

β-Amyloid protein (Aβ) is thought to cause neuronal loss in Alzheimer’s disease (AD). Aβ treatment promotes the re-activation of a mitotic cycle and induces rapid apoptotic death of neurons. However, the signaling pathways mediating cell-cycle activation during neuron apoptosis have not been determi...

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Bibliographic Details
Main Authors: Li Zhou, Di Chen, Xu-Ming Huang, Fei Long, Hua Cai, Wen-Xia Yao, Zhong-Cheng Chen, Zhi-Jian Liao, Zhe-Zhi Deng, Sha Tan, Yi-Long Shan, Wei Cai, Yu-Ge Wang, Ri-Hong Yang, Nan Jiang, Tao Peng, Ming-Fan Hong, Zheng-Qi Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Wnt5a
β-Amyloid protein
Alzheimer’s disease
cortical neuron
apoptosis
cell-cycle activation
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00281/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00281/full

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