N-terminal Ile-Orn- and Trp-Orn-motif repeats enhance membrane interaction and increase the antimicrobial activity of apidaecins against Pseudomonas aeruginosa

N-terminal Ile-Orn- and Trp-Orn-motif repeats enhance membrane interaction and increase the antimicrobial activity of apidaecins against Pseudomonas aeruginosa

The Gram-negative bacterium Pseudomonas aeruginosa is a life-threatening nosocomial pathogen due to its generally low susceptibility towards antibiotics. Furthermore, many strains have acquired resistance mechanisms requiring new antimicrobials with novel mechanisms to enhance treatment options. Pro...

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Bibliographic Details
Main Authors: Martina E. C. Bluhm, Viktoria A. F. Schneider, Ingo eSchäfer, Stefania ePiantavigna, Tina eGoldbach, Daniel eKnappe, Peter eSeibel, Lisandra L. Martin, Edwin J. A. Veldhuizen, Ralf eHoffmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
antibiotic
Transmission Electron Microscopy (TEM)
confocal fluorescence microscopy
Quartz crystal microbalance (QCM)
Cell uptake
Apidaecin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00039/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00039/full

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