SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

Metastatic disease is the major reason for breast cancer-related deaths; therefore, a better understanding of this process and its players is needed. Here the authors report the role of SIRT7 in inhibiting SMAD4-mediated breast cancer metastasis providing a possible therapeutic avenue.

Bibliographic Details
Main Authors: Xiaolong Tang, Lei Shi, Ni Xie, Zuojun Liu, Minxian Qian, Fanbiao Meng, Qingyang Xu, Mingyan Zhou, Xinyue Cao, Wei-Guo Zhu, Baohua Liu
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00396-9

Internet

https://doi.org/10.1038/s41467-017-00396-9

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