Identification of Novel BRCA1 and RAD50 Mutations Associated With Breast Cancer Predisposition in Tunisian Patients

Identification of Novel BRCA1 and RAD50 Mutations Associated With Breast Cancer Predisposition in Tunisian Patients

BackgroundDeleterious mutations on BRCA1/2 genes are known to confer high risk of developing breast and ovarian cancers. The identification of these mutations not only helped in selecting high risk individuals that need appropriate prevention approaches but also led to the development of the PARP-in...

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Main Authors: Najah Mighri, Yosr Hamdi, Maroua Boujemaa, Houcemeddine Othman, Sonia Ben Nasr, Houda El Benna, Nesrine Mejri, Soumaya Labidi, Jihen Ayari, Olfa Jaidene, Hanen Bouaziz, Mariem Ben Rekaya, Ridha M’rad, Abderrazek Haddaoui, Khaled Rahal, Hamouda Boussen, Samir Boubaker, Sonia Abdelhak
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Genetics
Subjects:
breast cancer
genetic screening
BRCA1-founder mutation
next-generation sequencing
novel mutation
RAD50
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.552971/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2020.552971/full

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