The enhancer landscape during early neocortical development reveals patterns of dense regulation and co-option.

Genetic studies have identified a core set of transcription factors and target genes that control the development of the neocortex, the region of the human brain responsible for higher cognition. The specific regulatory interactions between these factors, many key upstream and downstream genes, and...

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Bibliographic Details
Main Authors: Aaron M Wenger, Shoa L Clarke, James H Notwell, Tisha Chung, Geetu Tuteja, Harendra Guturu, Bruce T Schaar, Gill Bejerano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3757057?pdf=render