Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes

Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes

Direct acting antivirals (DAAs) revolutionized the therapy of chronic hepatitis C infection. However, unexpected high recurrence rates of hepatocellular carcinoma (HCC) after DAA treatment became an issue in patients with advanced cirrhosis and fibrosis. In this study, we aimed to investigate an imp...

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Bibliographic Details
Main Authors: Denisa Bojkova, Sandra Westhaus, Rui Costa, Lejla Timmer, Nora Funkenberg, Marek Korencak, Hendrik Streeck, Florian Vondran, Ruth Broering, Stefan Heinrichs, Karl S Lang, Sandra Ciesek
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
direct-acting antivirals
HCV
HCC recurrence
nucleotide analogue
EGFR pathway
Online Access:https://www.mdpi.com/2073-4409/9/4/1003

Internet

https://www.mdpi.com/2073-4409/9/4/1003

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