Curcumin analog A13 alleviates oxidative stress by activating Nrf2/ARE pathway and ameliorates fibrosis in the myocardium of high-fat-diet and streptozotocin-induced diabetic rats

Curcumin analog A13 alleviates oxidative stress by activating Nrf2/ARE pathway and ameliorates fibrosis in the myocardium of high-fat-diet and streptozotocin-induced diabetic rats

Abstract Background Diabetes mellitus is an important risk factor for cardiomyopathy. Increasing oxidative stress may be one of the main factors of diabetic cardiomyopathy. A13, a newly synthesized curcumin analog, was proved to be superior to curcumin in biological activity. However, little know ab...

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Bibliographic Details
Main Authors: Lanting Xiang, Qiongying Zhang, Chen Chi, Gu Wu, Zhongmin Lin, Jianmin Li, Qianru Gu, Guorong Chen
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Diabetes mellitus
Myocardium
Oxidative stress
Curcumin analog
Online Access:https://doi.org/10.1186/s13098-019-0485-z

Internet

https://doi.org/10.1186/s13098-019-0485-z

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