Using microarrays to facilitate positional cloning: identification of tomosyn as an inhibitor of neurosecretion.
Forward genetic screens have been used as a powerful strategy to dissect complex biological pathways in many model systems. A significant limitation of this approach has been the time-consuming and costly process of positional cloning and molecular characterization of the mutations isolated in these...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-07-01
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| Series: | PLoS Genetics |
| Online Access: | http://dx.doi.org/10.1371/journal.pgen.0010002 |