Cohesin promotes HSV-1 lytic transcription by facilitating the binding of RNA Pol II on viral genes

Abstract Background Herpes Simplex Virus type I (HSV-1) is a large double-stranded DNA virus that enters productive infection in epithelial cells and reorganizes the host nucleus. Cohesin, a major constituent of interphase and mitotic chromosomes comprised of SMC1, SMC3, and SCC1 (Mcd1/Rad21), SCC3...

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Bibliographic Details
Main Authors: Xin Li, Yafen Yu, Fengchao Lang, Guijun Chen, Erlin Wang, Lihong Li, Zhuoran Li, Liping Yang, Xia Cao, Nigel W. Fraser, Jumin Zhou
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Virology Journal
Subjects:
Online Access:https://doi.org/10.1186/s12985-021-01495-2