GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny

<p>Abstract</p> <p>Genomic instability (GIN) and chromosome instability (CIN) are two closely related ways to produce a variety of pathogenic conditions, i.e. cancer, neurodegeneration, chromosomal and genomic diseases. The GIN and CIN manifestation that possesses the most apprecia...

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Bibliographic Details
Main Authors: Iourov Ivan Y, Vorsanova Svetlana G, Yurov Yuri B
Format: Article
Language:English
Published: BMC 2009-11-01
Series:Molecular Cytogenetics
Online Access:http://www.molecularcytogenetics.org/content/2/1/23