Transcriptome profiling of spinal muscular atrophy motor neurons derived from mouse embryonic stem cells.

Transcriptome profiling of spinal muscular atrophy motor neurons derived from mouse embryonic stem cells.

Proximal spinal muscular atrophy (SMA) is an early onset, autosomal recessive motor neuron disease caused by loss of or mutation in SMN1 (survival motor neuron 1). Despite understanding the genetic basis underlying this disease, it is still not known why motor neurons (MNs) are selectively affected...

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Bibliographic Details
Main Authors: Miho Maeda, Ashlee W Harris, Brewster F Kingham, Casey J Lumpkin, Lynn M Opdenaker, Suzanne M McCahan, Wenlan Wang, Matthew E R Butchbach
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4156416?pdf=render

Internet

http://europepmc.org/articles/PMC4156416?pdf=render

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