Discovery of Novel 2,4-Dianilinopyrimidine Derivatives Containing 4-(Morpholinomethyl)phenyl and <i>N</i>-Substituted Benzamides as Potential FAK Inhibitors and Anticancer Agents

Discovery of Novel 2,4-Dianilinopyrimidine Derivatives Containing 4-(Morpholinomethyl)phenyl and <i>N</i>-Substituted Benzamides as Potential FAK Inhibitors and Anticancer Agents

Focal adhesion kinase (FAK) is responsible for the development and progression of various malignancies. With the aim to explore novel FAK inhibitors as anticancer agents, a series of 2,4-dianilinopyrimidine derivatives <b>8a</b>–<b>8i</b> and <b>9a</b>–<b>9g...

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Bibliographic Details
Main Authors: Chun Han, Kemin Shen, Shijun Wang, Zhijun Wang, Feng Su, Xi Wu, Xiaoqin Hu, Mengyao Li, Jing Han, Lintao Wu
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
FAK inhibitor
2,4-dianilinopyrimidine
4-(morpholinomethyl)phenyl
<i>N</i>-substituted benzamides
anticancer
molecular docking
Online Access:https://www.mdpi.com/1420-3049/26/14/4187

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https://www.mdpi.com/1420-3049/26/14/4187

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