Identification and in vivo characterization of a brain-penetrating nanobody

Identification and in vivo characterization of a brain-penetrating nanobody

Abstract Background Preclinical models to determine blood to brain transport ability of therapeutics are often ambiguous. In this study a method is developed that relies on CNS target-engagement and is able to rank brain-penetrating capacities. This method led to the discovery of an anti-transferrin...

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Bibliographic Details
Main Authors: Y Wouters, T Jaspers, B De Strooper, M Dewilde
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Fluids and Barriers of the CNS
Subjects:
Nanobody
VHH
Transferrin receptor
Neurotensin
Blood–brain barrier
Receptor-mediated transcytosis
Online Access:http://link.springer.com/article/10.1186/s12987-020-00226-z

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http://link.springer.com/article/10.1186/s12987-020-00226-z

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