Label-free quantitative proteomics identifies transforming growth factor β1 (TGF-β1) as an inhibitor of adipogenic transformation in OP9-DL1 cells and primary thymic stromal cells

Label-free quantitative proteomics identifies transforming growth factor β1 (TGF-β1) as an inhibitor of adipogenic transformation in OP9-DL1 cells and primary thymic stromal cells

Abstract Background Adipocyte accumulation is a predominant feature of age-related thymic involution, but the mechanisms responsible for thymic adipogenesis remain to be elucidated. The aim of this study was to identify key regulators in thymic adipogenesis. We used rosiglitazone, a potent peroxisom...

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Bibliographic Details
Main Authors: Jianxin Tan, Yajun Wang, Siliang Wang, Simeng Wu, Zhe Yuan, Xike Zhu
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Cell & Bioscience
Subjects:
Thymic involution
Adipocytes
Proteomics
TGF-β1
PPARγ
Wnt/β-catenin
Online Access:http://link.springer.com/article/10.1186/s13578-019-0311-1

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http://link.springer.com/article/10.1186/s13578-019-0311-1

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