Lithium Reduces Migration and Collagen Synthesis Activity in Human Cardiac Fibroblasts by Inhibiting Store-Operated Ca<sup>2+</sup> Entry

Lithium Reduces Migration and Collagen Synthesis Activity in Human Cardiac Fibroblasts by Inhibiting Store-Operated Ca<sup>2+</sup> Entry

Cardiac fibrosis plays a vital role in the pathogenesis of heart failure. Fibroblast activity is enhanced by increases in store-operated Ca<sup>2+</sup> entry (SOCE) and calcium release-activated calcium channel protein 1 (Orai1) levels. Lithium regulates SOCE; however, whether therapeut...

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Bibliographic Details
Main Authors: Pao-Huan Chen, Cheng-Chih Chung, Yuan-Feng Lin, Yu-Hsun Kao, Yi-Jen Chen
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
lithium
antifibrosis
cardioprotection
Ca2+ release-activate Ca2+ channel
intracellular Ca2+ homeostasis
Online Access:https://www.mdpi.com/1422-0067/22/2/842

Internet

https://www.mdpi.com/1422-0067/22/2/842

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