Centrosomal pre-integration latency of HIV-1 in quiescent cells

Centrosomal pre-integration latency of HIV-1 in quiescent cells

<p>Abstract</p> <p>Human immunodeficiency virus type 1 (HIV-1) efficiently replicates in dividing and non-dividing cells. However, HIV-1 infection is blocked at an early post-entry step in quiescent CD4+ T cells <it>in vitro</it>. The molecular basis of this restriction...

Full description

Bibliographic Details
Main Authors: Emiliani Stéphane, Roingeard Philippe, Tobaly-Tapiero Joëlle, Giron Marie-Lou, Clave Emmanuel, Lehmann-Che Jacqueline, Zamborlini Alessia, Toubert Antoine, de Thé Hugues, Saïb Ali
Format: Article
Language:English
Published: BMC 2007-09-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/4/1/63
id doaj-617f61e285f644cfbee148edd352ba47
record_format Article
spelling doaj-617f61e285f644cfbee148edd352ba472020-11-24T22:21:51ZengBMCRetrovirology1742-46902007-09-01416310.1186/1742-4690-4-63Centrosomal pre-integration latency of HIV-1 in quiescent cellsEmiliani StéphaneRoingeard PhilippeTobaly-Tapiero JoëlleGiron Marie-LouClave EmmanuelLehmann-Che JacquelineZamborlini AlessiaToubert Antoinede Thé HuguesSaïb Ali<p>Abstract</p> <p>Human immunodeficiency virus type 1 (HIV-1) efficiently replicates in dividing and non-dividing cells. However, HIV-1 infection is blocked at an early post-entry step in quiescent CD4+ T cells <it>in vitro</it>. The molecular basis of this restriction is still poorly understood. Here, we show that in quiescent cells, incoming HIV-1 sub-viral complexes concentrate and stably reside at the centrosome for several weeks. Upon cell activation, viral replication resumes leading to viral gene expression. Thus, HIV-1 can persist in quiescent cells as a stable, centrosome-associated, pre-integration intermediate.</p> http://www.retrovirology.com/content/4/1/63
collection DOAJ
language English
format Article
sources DOAJ
author Emiliani Stéphane
Roingeard Philippe
Tobaly-Tapiero Joëlle
Giron Marie-Lou
Clave Emmanuel
Lehmann-Che Jacqueline
Zamborlini Alessia
Toubert Antoine
de Thé Hugues
Saïb Ali
spellingShingle Emiliani Stéphane
Roingeard Philippe
Tobaly-Tapiero Joëlle
Giron Marie-Lou
Clave Emmanuel
Lehmann-Che Jacqueline
Zamborlini Alessia
Toubert Antoine
de Thé Hugues
Saïb Ali
Centrosomal pre-integration latency of HIV-1 in quiescent cells
Retrovirology
author_facet Emiliani Stéphane
Roingeard Philippe
Tobaly-Tapiero Joëlle
Giron Marie-Lou
Clave Emmanuel
Lehmann-Che Jacqueline
Zamborlini Alessia
Toubert Antoine
de Thé Hugues
Saïb Ali
author_sort Emiliani Stéphane
title Centrosomal pre-integration latency of HIV-1 in quiescent cells
title_short Centrosomal pre-integration latency of HIV-1 in quiescent cells
title_full Centrosomal pre-integration latency of HIV-1 in quiescent cells
title_fullStr Centrosomal pre-integration latency of HIV-1 in quiescent cells
title_full_unstemmed Centrosomal pre-integration latency of HIV-1 in quiescent cells
title_sort centrosomal pre-integration latency of hiv-1 in quiescent cells
publisher BMC
series Retrovirology
issn 1742-4690
publishDate 2007-09-01
description <p>Abstract</p> <p>Human immunodeficiency virus type 1 (HIV-1) efficiently replicates in dividing and non-dividing cells. However, HIV-1 infection is blocked at an early post-entry step in quiescent CD4+ T cells <it>in vitro</it>. The molecular basis of this restriction is still poorly understood. Here, we show that in quiescent cells, incoming HIV-1 sub-viral complexes concentrate and stably reside at the centrosome for several weeks. Upon cell activation, viral replication resumes leading to viral gene expression. Thus, HIV-1 can persist in quiescent cells as a stable, centrosome-associated, pre-integration intermediate.</p>
url http://www.retrovirology.com/content/4/1/63
work_keys_str_mv AT emilianistephane centrosomalpreintegrationlatencyofhiv1inquiescentcells
AT roingeardphilippe centrosomalpreintegrationlatencyofhiv1inquiescentcells
AT tobalytapierojoelle centrosomalpreintegrationlatencyofhiv1inquiescentcells
AT gironmarielou centrosomalpreintegrationlatencyofhiv1inquiescentcells
AT claveemmanuel centrosomalpreintegrationlatencyofhiv1inquiescentcells
AT lehmannchejacqueline centrosomalpreintegrationlatencyofhiv1inquiescentcells
AT zamborlinialessia centrosomalpreintegrationlatencyofhiv1inquiescentcells
AT toubertantoine centrosomalpreintegrationlatencyofhiv1inquiescentcells
AT dethehugues centrosomalpreintegrationlatencyofhiv1inquiescentcells
AT saibali centrosomalpreintegrationlatencyofhiv1inquiescentcells
_version_ 1725769355007885312

Similar Items