Design and experimental validation of the action of small molecule-based inhibitors of the FADD protein

Design and experimental validation of the action of small molecule-based inhibitors of the FADD protein

CD95 is one of the best studied members of the death receptor family. Activation of CD95 leads to the induction of the cell death programme, apoptosis, via formation of the death-inducing signaling complex (DISC). FA DD is a key adaptor protein for the formation of the C D95 DISC and activation of c...

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Bibliographic Details
Main Authors: N. V. Ivanisenko, L. Hillert, V. A. Ivanisenko, I. N. Lavrik
Format: Article
Language:English
Published: Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences 2016-01-01
Series:Vavilovskij Žurnal Genetiki i Selekcii
Subjects:
apoptosis
cd95
fa dd
molecular modeling
disc
caspase
Online Access:https://vavilov.elpub.ru/jour/article/view/490

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