Exosome release and neuropathology induced by α-synuclein: new insights into protective mechanisms of Drp1 inhibition

Exosome release and neuropathology induced by α-synuclein: new insights into protective mechanisms of Drp1 inhibition

Abstract Targeting alpha-synuclein (α-syn) as a therapeutic strategy for Parkinson’s disease (PD) has been intensively pursued largely due to its well-recognized pathogenic role. Since its discovery as the first familial link to PD over two decades ago, this protein has been associated with multiple...

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Bibliographic Details
Main Authors: Rebecca Z. Fan, Min Guo, Shouqing Luo, Mei Cui, Kim Tieu
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Acta Neuropathologica Communications
Subjects:
Parkinson’s disease
Mitochondrial dynamics
Neurodegeneration
Alpha-synuclein
Autophagy
Protein aggregation
Online Access:http://link.springer.com/article/10.1186/s40478-019-0821-4

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http://link.springer.com/article/10.1186/s40478-019-0821-4

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