Combinational spinal GAD65 gene delivery and systemic GABA-mimetic treatment for modulation of spasticity.

Loss of GABA-mediated pre-synaptic inhibition after spinal injury plays a key role in the progressive increase in spinal reflexes and the appearance of spasticity. Clinical studies show that the use of baclofen (GABA(B) receptor agonist), while effective in modulating spasticity is associated with m...

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Bibliographic Details
Main Authors:	Osamu Kakinohana, Michael P Hefferan, Atsushi Miyanohara, Tetsuya Nejime, Silvia Marsala, Stefan Juhas, Jana Juhasova, Jan Motlik, Karolina Kucharova, Jan Strnadel, Oleksandr Platoshyn, Peter Lazar, Jan Galik, Laurent Vinay, Martin Marsala
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3264568?pdf=render

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http://europepmc.org/articles/PMC3264568?pdf=render

Combinational spinal GAD65 gene delivery and systemic GABA-mimetic treatment for modulation of spasticity.

Internet

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