Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma.

Global DNA hypomethylation is a characteristic feature of cancer cells that closely associates with chromosomal instability (CIN). However, the association between these characteristics during hepatocarcinogenesis remains unclear. Herein, we determined the relationship between hypomethylation and CI...

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Bibliographic Details
Main Authors: Naoshi Nishida, Masatoshi Kudo, Takafumi Nishimura, Tadaaki Arizumi, Masahiro Takita, Satoshi Kitai, Norihisa Yada, Satoru Hagiwara, Tatsuo Inoue, Yasunori Minami, Kazuomi Ueshima, Toshiharu Sakurai, Naosuke Yokomichi, Takeshi Nagasaka, Ajay Goel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023736/pdf/?tool=EBI