Mice lacking alpha-synuclein are resistant to mitochondrial toxins

Mice lacking alpha-synuclein are resistant to mitochondrial toxins

Abnormalities in the function of α-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). We found that α-synuclein-deficient mice are resistant to MPTP-induced degeneration of dopaminergic neurons. There was dose-dependent protection against loss of both dopamine in the stri...

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Bibliographic Details
Main Authors:	Peter Klivenyi, Donald Siwek, Gabrielle Gardian, Lichuan Yang, Anatoly Starkov, Carine Cleren, Robert J. Ferrante, Neil W. Kowall, Asa Abeliovich, M. Flint Beal
Format:	Article
Language:	English
Published:	Elsevier 2006-03-01
Series:	Neurobiology of Disease
Subjects:	MPTP Paraquat 3-Nitropropionic acid Malonate MPP+ MPP+ levels
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996105002421

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