Mice lacking alpha-synuclein are resistant to mitochondrial toxins

Mice lacking alpha-synuclein are resistant to mitochondrial toxins

Abnormalities in the function of α-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). We found that α-synuclein-deficient mice are resistant to MPTP-induced degeneration of dopaminergic neurons. There was dose-dependent protection against loss of both dopamine in the stri...

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Bibliographic Details
Main Authors: Peter Klivenyi, Donald Siwek, Gabrielle Gardian, Lichuan Yang, Anatoly Starkov, Carine Cleren, Robert J. Ferrante, Neil W. Kowall, Asa Abeliovich, M. Flint Beal
Format: Article
Language:English
Published: Elsevier 2006-03-01
Series:Neurobiology of Disease
Subjects:
MPTP
Paraquat
3-Nitropropionic acid
Malonate
MPP+
MPP+ levels
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002421

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http://www.sciencedirect.com/science/article/pii/S0969996105002421

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