Rainbow Trout IgM+ B Cells Preferentially Respond to Thymus-Independent Antigens but Are Activated by CD40L

Rainbow Trout IgM+ B Cells Preferentially Respond to Thymus-Independent Antigens but Are Activated by CD40L

In the absence of class switch recombination and germinal centers, the mechanisms through which B cells from teleost fish mount extrafollicular immunoglobulin M (IgM) memory responses remains mostly unexplored. In this report, we demonstrate that teleost IgM+ B cells respond to CD40L, a thymus-depen...

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Bibliographic Details
Main Authors: Aitor G. Granja, Pedro Perdiguero, Alba Martín-Martín, Patricia Díaz-Rosales, Irene Soleto, Carolina Tafalla
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
teleost fish
B cells
IgM
extrafollicular responses
CD40L
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02902/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02902/full

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