Fusobacterium nucleatum Aggravates the Progression of Colitis by Regulating M1 Macrophage Polarization via AKT2 Pathway

Fusobacterium nucleatum Aggravates the Progression of Colitis by Regulating M1 Macrophage Polarization via AKT2 Pathway

Disordered intestinal flora and discordant immune response are associated with the development of ulcerative colitis (UC). Recent work has described the ability of macrophages to undergo repolarization toward a proinflammatory M1 or anti-inflammatory M2 phenotype in response to particular bacterium-...

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Bibliographic Details
Main Authors: Le Liu, Liping Liang, Huifen Liang, Mingming Wang, Bingyun Lu, Meng Xue, Jun Deng, Ye Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
Fusobacterium nucleatum
ulcerative colitis
gut microbiota
M1 macrophage
mucosal barrier
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01324/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01324/full

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