The KDM Inhibitor GSKJ4 Triggers CREB Downregulation via a Protein Kinase A and Proteasome-Dependent Mechanism in Human Acute Myeloid Leukemia Cells

The KDM Inhibitor GSKJ4 Triggers CREB Downregulation via a Protein Kinase A and Proteasome-Dependent Mechanism in Human Acute Myeloid Leukemia Cells

Acute myeloid leukemia (AML) is a progressive hematopoietic-derived cancer arising from stepwise genetic mutations of the myeloid lineage. cAMP response element-binding protein (CREB) is a nuclear transcription factor, which plays a key role in the multistep process of leukemogenesis, thus emerging...

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Bibliographic Details
Main Authors: Michela Illiano, Mariarosaria Conte, Alessia Salzillo, Angela Ragone, Annamaria Spina, Angela Nebbioso, Lucia Altucci, Luigi Sapio, Silvio Naviglio
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
GSKJ4
acute myeloid leukemia (AML)
cAMP response element-binding protein (CREB) downregulation
proteasome-mediated degradation
protein kinase A (PKA)
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00799/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00799/full

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