A Novel Triplet-Primed PCR Assay to Detect the Full Range of Trinucleotide CAG Repeats in the Huntingtin Gene (<i>HTT</i>)

A Novel Triplet-Primed PCR Assay to Detect the Full Range of Trinucleotide CAG Repeats in the Huntingtin Gene (<i>HTT</i>)

The expanded CAG repeat number in <i>HTT</i> gene causes Huntington disease (HD), which is a severe, dominant neurodegenerative illness. The accurate determination of the expanded allele size is crucial to confirm the genetic status in symptomatic and presymptomatic at-risk subjects and...

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Bibliographic Details
Main Authors: Alessandro De Luca, Annunziata Morella, Federica Consoli, Sergio Fanelli, Julie R. Thibert, Sarah Statt, Gary J. Latham, Ferdinando Squitieri
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
Huntington disease
<i>HTT</i>-CAG repeats
novel diagnostic test
TP-PCR
Online Access:https://www.mdpi.com/1422-0067/22/4/1689

Internet

https://www.mdpi.com/1422-0067/22/4/1689

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