Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer

Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer

Abstract Background Prostate cancer is poorly responsive to immune checkpoint inhibition, yet a combination with radiotherapy may enhance the immune response. In this study, we combined radiotherapy with immune checkpoint inhibition (iRT) in a castration-resistant prostate cancer (CRPC) preclinical...

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Bibliographic Details
Main Authors: Stephanie O. Dudzinski, Brent D. Cameron, Jian Wang, Jeffrey C. Rathmell, Todd D. Giorgio, Austin N. Kirschner
Format: Article
Language:English
Published: BMJ Publishing Group 2019-08-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Immunotherapy/Antibody immunotherapy
Radiation oncology/combined modality therapies
Model organisms/animal models of cancer
Genitourinary cancers/prostate cancer
Radiobiology/tumor microenvironment and modification
Abscopal effect
Online Access:http://link.springer.com/article/10.1186/s40425-019-0704-z

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http://link.springer.com/article/10.1186/s40425-019-0704-z

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